Do Tougher Licensing Provisions Limit Occupational Entry? The Case of Dentistry

The effect of licensing as a mechanism to control entry into occupations has been a neglected area of both regulation and labor market research. This study examines the role of occupational licensing for entry into dentistry, an occupation with standards that vary by state. Our research first closely replicates Freeman's previous work on labor market cobwebs by employing national data to examine purely market phenomena in the determination of training for the dental profession. We subsequently approximate the government barrier to practice in the profession by adding a weighted average state examination pass rate to the previous model. Next, we employ pooled cross-section time series analysis to explore market determinants of professional entry with state level data. Finally, these results are supplemented by measures of statutory and pass rate entry restrictiveness. Our most consistent evidence suggests that a higher state licensing failure rate deters entry into dental practice.

Ectopic Gene Conversions in the Genome of Ten Hemiascomycete Yeast Species

We characterized ectopic gene conversions in the genome of ten hemiascomycete yeast species. Of the ten species, three diverged prior to the whole genome duplication (WGD) event present in the yeast lineage and seven diverged after it. We analyzed gene conversions from three separate datasets: paralogs from the three pre-WGD species, paralogs from the seven post-WGD species, and common ohnologs from the seven post-WGD species. Gene conversions have similar lengths and frequency and occur between sequences having similar degrees of divergence, in paralogs from pre- and post-WGD species. However, the sequences of ohnologs are both more divergent and less frequently converted than those of paralogs. This likely reflects the fact that ohnologs are more often found on different chromosomes and are evolving under stronger selective pressures than paralogs. Our results also show that ectopic gene conversions tend to occur more frequently between closely linked genes. They also suggest that the mechanisms responsible for the loss of introns in S. cerevisiae are probably also involved in the gene 3′-end gene conversion bias observed between the paralogs of this species

New Insights into the Pathogenesis of Ovarian Cancer: Oxidative Stress

Ovarian cancer is the leading cause of death from gynecologic malignancies yet the underlying pathophysiology is not clearly established. Epithelial ovarian cancer (EOC) has long been considered a heterogeneous disease with respect to histopathology, molecular biology, and clinical outcome. Treatment of ovarian cancer includes a combination of cytoreductive surgery and combination chemotherapy, with platinums and taxanes. Despite initial success, over 75% of patients with advanced disease will relapse around 18 months and the overall 5-year survival is approximately 50%. Cancer cells are known to be under intrinsic oxidative stress, which alters their metabolic activity and reduces apoptosis. Epithelial ovarian cancer has been shown to manifest a persistent pro-oxidant state as evident by the upregulation of several key oxidant enzymes in EOC tissues and cells. In the light of our scientific research and the most recent experimental and clinical observations, this chapter provides the reader with up to date most relevant findings on the role of oxidative stress in the pathogenesis and prognosis of ovarian cancer, as well as a novel mechanism of apoptosis/survival in EOC cells

Decomposition techniques for policy refinement.

The automation of policy refinement, whilst promising great benefits for policy-based management, has hitherto received relatively little treatment in the literature, with few concrete approaches emerging. In this paper we present initial steps towards a framework for automated distributed policy refinement for both obligation and authorization policies. We present examples drawn from military scenarios, describe details of our formalism and methods for action decomposition, and discuss directions for future research. © 2010 IEEE.Accepted versio

Natural Wormholes as Gravitational Lenses

Visser has suggested traversable 3-dimensional wormholes that could plausibly form naturally during Big Bang inflation. A wormhole mouth embedded in high mass density might accrete mass, giving the other mouth a net *negative* mass of unusual gravitational properties. The lensing of such a gravitationally negative anomalous compact halo object (GNACHO) will enhance background stars with a time profile that is observable and qualitatively different from that recently observed for massive compact halo objects (MACHOs) of positive mass. We recommend that MACHO search data be analyzed for GNACHOs.Comment: 4 pages; plus 4 figures; ReV_TeX 3.0; DOE/ER/40537-001/NPL94-07-01

EAGLE multi-object AO concept study for the E-ELT

EAGLE is the multi-object, spatially-resolved, near-IR spectrograph instrument concept for the E-ELT, relying on a distributed Adaptive Optics, so-called Multi Object Adaptive Optics. This paper presents the results of a phase A study. Using 84x84 actuator deformable mirrors, the performed analysis demonstrates that 6 laser guide stars and up to 5 natural guide stars of magnitude R<17, picked-up in a 7.3' diameter patrol field of view, allow us to obtain an overall performance in terms of Ensquared Energy of 35% in a 75x75 mas^2 spaxel at H band, whatever the target direction in the centred 5' science field for median seeing conditions. The computed sky coverage at galactic latitudes |b|~60 is close to 90%.Comment: 6 pages, to appear in the proceedings of the AO4ELT conference, held in Paris, 22-26 June 200

Discovery of a z=4.93, X-ray selected quasar by the Chandra Multiwavelength Project (ChamP)

We present X-ray and optical observations of CXOMP J213945.0-234655, a high redshift (z=4.93) quasar discovered through the Chandra Multiwavelength Project (ChaMP). This object is the most distant X-ray selected quasar published, with an X-ray luminosity of L(X)=5.9x10^44 erg/s (measured in the 0.3-2.5 keV band and corrected for Galactic absorption). CXOMP J213945.0-234655 is a g' dropout object (>26.2), with r'=22.87 and i'=21.36. The rest-frame X-ray to optical flux ratio is similar to quasars at lower redshifts and slightly X-ray bright relative to z>4 optically-selected quasars observed with Chandra. The ChaMP is beginning to acquire significant numbers of high redshift quasars to investigate the unobscured X-ray luminosity function out to z~5.Comment: Published in ApJ Letters; 4 pages; 3 figures; http://hea-www.harvard.edu/CHAMP

dREAM co-operates with insulator-binding proteins and regulates expression at divergently paired genes

dREAM complexes represent the predominant form of E2F/RBF repressor complexes in Drosophila. dREAM associates with thousands of sites in the fly genome but its mechanism of action is unknown. To understand the genomic context in which dREAM acts we examined the distribution and localization of Drosophila E2F and dREAM proteins. Here we report a striking and unexpected overlap between dE2F2/dREAM sites and binding sites for the insulator-binding proteins CP190 and Beaf-32. Genetic assays show that these components functionally co-operate and chromatin immunoprecipitation experiments on mutant animals demonstrate that dE2F2 is important for association of CP190 with chromatin. dE2F2/dREAM binding sites are enriched at divergently transcribed genes, and the majority of genes upregulated by dE2F2 depletion represent the repressed half of a differentially expressed, divergently transcribed pair of genes. Analysis of mutant animals confirms that dREAM and CP190 are similarly required for transcriptional integrity at these gene pairs and suggest that dREAM functions in concert with CP190 to establish boundaries between repressed/activated genes. Consistent with the idea that dREAM co-operates with insulator-binding proteins, genomic regions bound by dREAM possess enhancer-blocking activity that depends on multiple dREAM components. These findings suggest that dREAM functions in the organization of transcriptional domains